This study is a randomised, double-blind trial involving 200 participants with newly diagnosed Parkinson’s, who will be randomly assigned in an 1:1 ratio to either nicotinamide riboside or placebo treatment for 52 weeks. OTHER DEVELOPMENTS TO WATCH FOR IN 2020 REGARDING GDNF: Another company working on GDNF is called Genecode. Neuroprotective approach: Plasma infusions. Only time will tell. This was an open label study, and we are still waiting to see the results published. Did he want an exact date?!? One of the most common of these genes is called GBA. Anti-inflammatory: vit D3 A valiant effort , Simon . Not quite Count Dracula, but there has been a lot of research exploring this idea (Click here to read a SoPD post on this topic). They are currently conducting a Phase I safety/tolerability trial of UB-312 in healthy volunteers and in participants with Parkinson’s. Interestingly, in early 2019 Denali and the pharma company Sanofi initiated two Phase I clinical trials of their RIPK1 inhibitor, DNL747. Any actions taken – based on what has been read on the website – are the sole responsibility of the reader. At the time of writing this post, we have not had any updates from AFFiRiS since May 2018 (Source). Your doctor may suggest you work with a physical therapist to learn an exercise program that works for you. There is no cure and “no treatment that can slow down or stop the disease process,” Kim said. Cellular waste disposal/recycling is referred to as autophagy. Latest events Carols for a Cure! A curative therapy for Parkinson’s is going to need to be personalised to each individual, with varying levels of each of the three component listed above. There are different types of neurotrophic factors which affect different types of neurons in different ways (one of my pet peeves is repetition of a word in a single sentence!). The loss of … https://youtu.be/PqLL9sIidZg, Wow! The amount of research being conducted is a very positive sign, however, and it suggests that 2020 will be an extremely productive year of Parkinson’s research. Most people do not require a DAT scan. For the purposes of full disclosure, where appropriate I will note the Trust’s involvement. Sign Up . But in late 2019, the Pharma company Biogen reported that one of their huge Phase III clinical trials did have a positive outcome and they are now petitioning the US FDA for market authorisation for their treatment, aducanumab (Click here to read more about this). Click here to subscribe to the Parkinson’s News Today Newsletter! The following list of clinical trials is labelled as “Neuroprotective approach: Additionals” as they could not be better grouped. Helping cells to clean themselves up by boosting waste disposal systems, we will hopefully make the cells healthier and function better. This is a phase II, 52 week trial of Ambroxol in 75 people with Parkinson’s Disease Dementia (Click here to read more about this trial). This study is scheduled to finish in 2021 (Click here to read more about this study). For example, there is a protein called alpha synuclein which is associated with Parkinson’s. Many of these nerve cells produce dopamine, a chemical messenger in the brain. This was a Phase I study evaluating the safety, tolerability and pharmacokinetics of this treatment, after single and multiple oral dose administration (Click here to read more about that study and click here for a previous SoPD post on this topic). FB-101 has now entered Phase I clinical testing in healthy volunteers (Click here to read more about that study) and that study is scheduled to finish mid 2020. Sleep Problems and Sleep Disorders: People with Parkinson’s disease often have sleep problems, including waking up frequently throughout the night, waking up early or falling asleep during the day. Inmune Bio has conducted a Phase I clinical study of XPro1595 in individuals with moderate Alzheimer’s, which was scheduled to finish in December 2019 (Click here to read more about this trial). Prior to this, a French study based on the public health data was published which showed that smokers had an 80 percent less chance to get Covid-19 as compared to non-smokers. The Phase III trial will involved 200 participants being treated for 2 years and is scheduled to complete in 2024 (Click here to read more about this trial and Click here to see the trial webpage). Change ). ESB1609 is a novel, orally administered, brain-penetrant, selective sphingosine 1-phosphate 5 (S1P5) receptor agonist. In addition, the much larger PD-STAT study which evaulating the statin Simvastastin in 230+ people with Parkinson’s is being conducted here in the UK (Click here to learn more about this study) is scheduled to finish in late 2020. Likewise, some individuals have only just been diagnosed, while others have lived with the condition for many years. Parkinsons Disease signs and symptoms can be different for everyone. Thank you so much, Simon, for the astounding amount of work you’ve put into it. The hope is that by inhibiting LRRK2, we will be able to slow down/halt the cell death and stablise the course of Parkinson’s. Another clinical trial of a GBA-targeted therapy that we will be seeking news about in 2020 was conducted by a biotech firm called Lysosomal Therapeutics. Emergency Helpline: I have had a number of readers requesting a SoPD post discussing the results of the two Nilotinib clinical trials. Very interesting. But the researchers then conducted a drug screen and identified a small molecule that promotes Miro1 degradation, and they found that this drug could rescue mulitple Parkinson’s models (Click here to read a previous SoPD post on the topic). The results of the NILO-PD study are not yet published, however, so to avoid any confusion, I am going to wait until those results are also available before writing that post. Multiple independent labs have demonstrated that this is a worthy target for Parkinson’s (Click here to read a review on this topic). Depending on the seriousness of your illness, several applications may be required to receive the expected results. It is very important for all readers of this post to appreciate that cell transplantation for Parkinson’s is still extremely experimental. This biotech company is focused on developing a novel class of vaccines that are fully synthetic (they call them ‘endobody vaccines‘) and can train the body to treat/prevent neurological condtions. Keapstone was set up in late 2017 to develop neuroprotective therapies for Parkinson’s that are focused on compounds that trigger a cellular defence system (specifically NRF2 activators) that helps protect brain cells from oxidative stress (Click here to read a previous SoPD post about this). That trial was scheduled to finish in late 2019, so we may (hopefully) hear news of the results and whether they are moving to Phase II in 2020. Find the Right Support You Need Search Now. And this trial is interesting given the announcement in late 2018 of positive results for an open label Phase II clinical trial of EPI-589 in motor neurone disease/ALS. Certain medications, toxins and other diseases can produce symptoms, similar to Parkinsons Disease, and then it is known as secondary Parkinsonism, which may be reversible. A clinical trial of Nicotinamide Riboside (a form of Vitamin B3) has started in Norway – it is called the ‘NOPARK’ Study. Once you have been treated with the Pluripotent Stem Cells the healing and repair of the damaged organs begin. Any actions taken by the reader based on reading this material is the sole responsibility of the reader. This Phase I open label study was designed to assess the safety/tolerability of increasing doses of UDCA, but is not expected to report results until 2022 (Click here to read more about this). These changes include: No specific test exists to diagnose Parkinsons Disease. For those interested in exercise, there are a lot of clinical trials that have just registered or recruiting (78 at the time of writing) which could be explored (Click here to read more about these). Genes provide the instructions for making some of the proteins, and some of the genes affected in Parkinson’s are involved in autophagy-related processes. This biotech firm uses a degradation tag (dTAG) for targeting pathogenic proteins that need to be disposed of (Click here to read recent research about this). Another experimental drug, called ENT-01, is currently being clinically tested a company called Enterin Inc. Both pain and PD conditions cause cortical excitability reduction, but mental representations techniques are thought to be able to counteract it, resulting also effective in chronic pain conditions. Ozone Therapy is effective for both activation of the cerebral microcirculation and increasing energy production by neurons, as recent studies have shown. Thank you to everyone who generously donates to Drive Away Parkinsons for Parkinson's Research. In 2019, a new GLP-1R agonist called NLY01 entered the clinical trial process. There is an ongoing European clinical trial called Transeuro which is using the fetal cell approach for Parkinson’s. In addition, while ENT-01 does not cross the blood brain barrier, the company has another compound Trodusquemine which does get into the brain. Creative Commons Attribution 4.0 International License Another neurotrophic factor that is currently in clinical trial is cerebral dopamine neurotrophic factor (CDNF). Ceftriaxone is a cephalosporin antibiotic, which has been reported to have beneficial effects in models of Parkinson’s (Click here and here for examples and click here to read a review about this drug). S1P5 provides a powerful target that is upstream to some of the autophagy-related (lysosomal) deficits associated with conditions like GBA-associated Parkinson’s (Click here to read more about this). Your doctor trained in nervous system conditions (neurologist) will diagnose Parkinsons Disease based on your medical history, a review of your signs and symptoms, and a neurological and physical examination. NeuroPore Therapies have out-licensed another small molecule alpha synuclein inhibitor called NPT200-11 to the pharma company UCB. Currently, there is no cure for the disease. You are welcome. We will be hoping for news on this front as well is 2020. The Latest Cure for Parkinsons Disease . Very curious. This drug is being developed by Neuraly Inc. A Phase I in healthy volunteers was conducted and completed by Neuraly in 2019 (Click here to read more about that study), and the company has now shifted to testing NLY01 in 200+ people with Parkinson’s in a large Phase II trial. Participants recieved 4 twice-per-week infusions of 1 unit of young plasma (from males ages between 18-25) and were then monitored over 8 weeks (Click here to read more about this study). The first of them is being conducted in Israel and involves 100 participants who have been evaluated for 6 months in a open label fashion (Click here to read more about this trial). Please understand that there is still a long way to go for all of these experimental therapies. And finally a new entrant to the small molecule inhibitors of alpha synuclein field is Anle138b which is being developed by the biotech firm MODAG. Neuroprotective approach: GLP-1R agonists. It never of course will be as fast as I want . In 2020, I am also hoping to hear news regarding sargramostim. Between 2017-2018, the company conducted the RASMET study, which was a Phase I safety clinical trial of ENT-01 (Click here for the details about this trial and click here to read a SoPD post on this topic). Researchers have targeted this protein as a means of slowing/halting Parkinson’s. "It would not be a cure for Parkinson's," he said. She argues that she can save money by manufacturing far fewer cell lines. The results have not been published yet, but the company’s website suggests that the “study established an excellent safety and tolerability profile in normal human volunteers” (Click here to read more). In addition, we must remember that a clinical trial is supposed to be an unbiased evaluation of a treatment. It will be interesting to see how things develop in 2020. (The Cure Parkinson’s Trust is a supporter of the Simvastatin study). Reduces rigidity As well as this, it has been shown to have a proven anti-inflammatory and antispasmodic action, improve microcirculation, increase the production of cellular energy, activate the mitochondrial antioxidant system and facilitate the elimination of cell catabolites. The study is published June 24, 2020 in Nature. Just a single treatment to inhibit PTB in mice converted native astrocytes, star-shaped support cells of the brain, into neurons that produce the neurotransmitter dopamine. This study of 10 participants is also a safety trial and is scheduled to finish in 2021 (Click here to read more about this study). We recommend a combination of several treatments that all work on the disease in a verity of beneficial ways. This approach generally involves boosting the waste disposal systems of the cell – in this manner, the cells can break down and dispose of excess proteins (like alpha synuclein) inside the cell before they have a chance to builds up and becomes toxic. Like I said in the post, the landscape is always changing. But Xpro1595 is different to current clinically approved TNF inhibitors, as it only neutralises soluble TNF, while not affecting trans-membrane TNF (this is an important difference). Researchers also recognize that, as the disease presents so differently in each patient, there may not be a single "cure" for Parkinson's disease. Phase I testing in healthy individuals finished in September 2019, so we have looking forward to hearing the results of this study in 2020 (Click here to read more about this trial). Overall improvement assessed by the unified Parkinson’s disease rating scale (UPDRS) . Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. Another new entrant to the GLP-1R agonist group is Peptron. This trial is an open label study, involving 13 subjects. When diagnosed, people with Parkinson’s have often had the disease for years and have lost over half of the dopamine producing cells in their brain. The female egg cell is chemically encouraged to start dividing and then it becoming a collection of cells that is called a blastocyst, which ultimately go on to contain embryonic stem cell-like cells. While some of the information discussed in this post may cause concern, please speak with your medical physician before attempting any change in an existing treatment regime. Read more. Neuroprotective approach: Fecal transplantion. 20th August 2020, 5:21 pm SCIENTISTS are on the brink of finding a cure for Parkinson’s disease after discovering what causes the illness and how it affects brain cells. Another company interested in LRRK2 is the pharmaceutical company Biogen. This means that stem cells can be used to treat a wide range of conditions, including Parkinson’s, where new cells can be used to repair and replace damaged tissue. If you know of a clinical trial that deserves a mention – please contact me. Another c-Abl inhibitor being targeted at Parkinson’s is FB-101, which is being developed by the biotech firms 1ST Biotherapeutics and Neuraly. Your speech may become soft or slurred. Immunotherapy involves boosting the body’s immune system to target specific toxic agents in the body. One-third of the participants received monthly infusions of placebo and two-thirds of the participants received monthly infusions of either mid- or high-doses of CDNF for 6 months (Click here to read more about this trial). These are vaccines for Parkinson’s, which targets the toxic form of alpha synuclein. Will be keeping an eye out for developments here. Scientific breakthroughs sometimes occur when scientists are not actively searching for them. Receptor-interacting protein kinase 1 (RIPK1) is a protein involved with multiple cellualr pathways leading to inflammation or cell death. This post would not be possible without those amazing resources. Also note that there another company called Anavex Life Sciences (AVXL) that is targeting various Central Nervous System Diseases (AD, PD, Rett, FTD ). Another form of ‘neuroprotective’ treatment that has been tested in Parkinson’s for a long time is neurotrophic factors. Pain is an under-reported but prevalent symptom in Parkinson’s Disease (PD), impacting patients’ quality of life. Both of these studies are not expected to report any results in 2020 (beyond an announcements of Part 1 completions for both studies). 2020 is going to be a busy year for Parkinson’s research, and I am genuinely concerned that posts like this are only going to raise expectations. Cell transplantation currently represents the most straight forward method of cell replacement therapy. But we're close to major breakthroughs. The company recently launched with seed funding to advance their personalized cell transplantation therapy approach for Parkinson’s (Click here to read the press release). Fox Foundation and The Silverstein Foundation funded them in early 2019 (Source). Placebo effect probably great, but if it works, fine. Fox Foundation's annual scientific conference and the only one in the world focused exclusively on Parkinson's disease drug development. Your doctor may suggest a specific single-photon emission computerized tomography SPECT scan called a dopamine transporter (DAT) scan. Aradippou Our mission is to obliterate Parkinson's once and for all. Limited preclinical research has been published in the west with this extract of an oriental fungus in models of Parkinson’s (for examples, click here and here), but the results of this clinical trial could be something to keep an eye out for in 2020. You could get lost in a long post like this. It is always a good meeting – focused on explaining the research in plain English – and this year has a fastastic line up of speakers (I’m just second or third fiddle). Parkinson’s disease sets in gradually over time. Statins are a class of cholesterol lowering drugs, which have demonstrated neuroprotective properties in preclinical models of Parkinson’s (Click here to read a SoPD post on this topic and click here to read a review on this topic). This study is being conducted in Norway by the Danish biotech firm Novo Nordisk. These usually occur in the later stages of Parkinson’s disease. 4.4. Flooding the brain with oxygen, slows neuronal degeneration, mobilises rejuvenating stem cells, and enhances angiogenesis (the growth of new blood vessels that nurture damaged areas). The Pluripotent Stem Cells and Hyperbaric Oxygen Treatment for Parkinson’s Disease has the ability to give a higher standard of living than is currently being experience by the patient, we have seen much of the signs and symptoms being reduced greatly. Remember to pace yourself. In fact, there are some cases of Parkinson’s that do not involve any accumulation of alpha synuclein at all. The Phase I ResTorbio clinical study is being conducted in New Zealand, and the trial is scheduled to finish in 2020 (Click here to read more about this trial and click here to read a SoPD post on this trial). Another GBA-related approach involves a drug called Venglustat (formerly known as GZ/SAR402671 & Ibiglustat) which is being conducted by the biotech company Sanofi Genzyme. While there are treatments to alleviate symptoms of Parkinson's disease, there is no known cure or preventive drug. As Lopez well knew. It will be interesting to see the results of that trial in 2020. *Patient feedback, articles and testimonials provided on this site are for informational purposes only and should not be considered as a guaranteed result for every case of illness. The theme this year is ‘When and how does Parkinson’s start‘. The second technique involves administering Stem Cells via intravenous insertion. In the ‘neuroprotection’ section, top of the list of news that we will be looking for in 2020 is the initition of a Phase III clinical trial for Bydureon/Exenatide. The 2020 Tom Isaacs Charity Golf Days. We will also be hoping to hear news from Prof Englund’s lab regarding new developments of activators of Nurr 1 (Click here to read a SoPD post on this topic). The participants were treated for 14 weeks (Click here to read more about this trial). Given that genetic variants in the GBA gene are the most common in Parkinson’s, a great deal of research is being conducted on this particular gene, with multiple clinical trials testing GBA-based therapies. Anle138b currently being targeted at Multiple System Atrophy – a neurodegenerative condition similar to Parkinson’s – but the company is keen to test the molecule in Parkinson’s as well (Click here to read a previous SoPD post about this topic). ( Log Out / nrf2 and antioxidants: vit D3, lipoic acid, melatonin They help to keep the lights on. Before that I was working as a Parkinson's research scientist at the University of Cambridge where I conducted both clinical- and lab-based research on Parkinson's. In addition, there is a clinical trial of a new formulation of Exenatide called Semaglutide in Parkinson’s. The stem cells derived from this process can be grown into neuronal cells before being transplanted into brain. Most of patients can have normal life as long as following the right protocol. Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Tumor Necrosis Factor (TNF) is a potent immune signaling molecule (a cytokine) and it is intimately involved in inflammation. It too is scheduled to finish in late 2020. And the fourth on-going stem cell-based cell transplantation clinical trial is the ‘induced pluripotent stem’ (or IPS) cell study being conducted in Kyoto, Japan (Click here to read a SoPD post on this topic). The Alzheimer’s clinical study was scheduled to complete in December 2019. In 2020, we will hopefully hear news about the results. Nor is this a definitive or exhaustive guide of what the next year holds for disease modification research (if you see anything important that I have missed – please contact me). Despite the set back with this GDNF trial, there is another GDNF trial that is investigating a gene therapy form of GDNF. These are two meetings that I can thoroughly recommend to readers who have never attended such an event. This study (called the SKY study) recruited 140 people with early Parkinson’s and treated them twice-daily for 9 months with Deferiprone (one of 4 different doses) or a placebo drug (Click here to read more about the details of this study). A person’s movements may change slightly. Share. In 2020, I will be curious to see if companies like Fujifilm/Cellular Dynamics or Novo Nordisk step up to the plate and start a clinical trial program focused on cell transplantation for Parkinson’s. The results of the Phase I RASMET study have been published (Click here to read them and click here to read the press release), and the company is currently conducting a Phase IIa ‘KARMET’ clinical study of ENT-01, which is scheduled to finish in October 2020 (Click here to read more about this study). Here at Poseidonia Healthcare, we offer a full range of treatments for Parkinsons Disease, here are a few benefits of the more popular treatments: Our Pluripotent Stem Cell Therapy can be administered in one of two ways. The treatment (or placebo) will be administered by intravenous infusion for 5 consecutive days at Week 1 and Week 13 of the study (Click here to read more about the details of this clinical study). As always you are most welcome. The first is the PASADENA study. This company signed a deal with Biogen in early 2019 to develop treatments for neurological disorders. There is a second clinical trial of UDCA which has been conducted at the University of Minnesota. In the case of Parkinson’s, this approach is primarily being focused on different forms of alpha synuclein. PARKIN is a protein that has many functions, and disruption of it is associated with increased risk of developing Parkinson’s. It will be assessing the safety and tolerability of GRF6021 over a period of 7 months. If determined to be safe, it could be interesting to further explore the idea of RIPK1 inhibition in Parkinson’s (particularly if upstream LRRK2 inhibition is difficult to tolerate long-term – no evidence of this to date though). My expectations are enthusiastically under control. Curax is developing a molecule that helps in the removal of a protein called Miro1. Not all of the direct approaches to slowing Parkinson’s involve targeting alpha synuclein protein. The indirect approach: GBA-based approaches. If so there is no cure for this disease. without much difficulty In addition, what is not apparent from a static view like this post is that the landscape is always changing – so quickly in fact that I know within a few days of publishing this post, there will be new announcements further changing that landscape. Loring says she’s developed that. Parkinson’s disease, a brain disorder that affects over 10 million people worldwide, is caused by the gradual loss of dopamine neurons. They use small molecule therapeutics to selectively target and correct RNA expression. In addition, I am the president of my local Parkinson's UK support branch in North Hertfordshire. In the image below, you can see rich brown areas of the putamen in panel A. This is a class of drug that has traditionally been used for treating diabetes, but has recently been repurposed for Parkinson’s. Tremors are common, but the disorder also commonly causes stiffness or slowing of movement. Stories 2019-2020 Stories 2018-2019 Stories 2016-2017 Stories 2014-2015 Stories 2012-2013 ... Daniel Otzen and his’ team of researchers hope to develop the first cure for Parkinson’s disease. The first of these anti-inflammatory approaches involves inhibiting the inflammasome. Importance Parkinson disease is the most common form of parkinsonism, a group of neurological disorders with Parkinson disease–like movement problems such as rigidity, slowness, and tremor. We will hopefully hear the results of this study in 2020. Resolvins: omega fatty acids+low dose aspirin It will also be interesting to learn more about Chamishi Therapeutics. This means that, in the future, researchers may be able to develop a more effective and less invasive treatment for Parkinson’s disease in humans. Unfortunately, there is only so much we can cover here. 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